Dave Douglas (Tim Allen) is a replacement area attorney in Los Angeles County that is prosecuting social researches instructor as well as lobbyist Justin Forrester (Joshua Leonard) for firebombing the pharmaceutical firm Grant and also Strictland. Forrester denies this, yet asserts that Grant and also Strictland has been taking part in prohibited animal experimentation. This ranges Douglas from his little girl Carly (Zena Grey), among Forrester's pupils.
The greedy geneticists working for Mr. Lance Strictland (Philip Baker Hall), led by Dr. Kozak (Robert Downey, Jr.), have stolen a 300-year-old sacred canine identifieded as Khyi Yang Po (a Bearded Collie) from a Tibetan abbey. The researchers identify that Khyi Yang Po's genetic sequence, when isolated and also taken into an inoculation, attacks as well as changes the cells and also DNA of a victim.
When Dave returns from job, he takes the pet out in the garage, after that the canine goes to get the newspaper. The pet dog offers him his newspaper, yet as Dave reaches for it, Khyi Yang Po bites him on the hand. The saliva enters into Dave's blood as well as DNA, infecting him.
In the continuous trial, Forrester affirms seeing the pets behaving like pet dogs, which triggers Dave's uncertainties about Grant as well as Strictland. When his dog-like behavior frustrates the judge, Dave is eliminated from the situation. Hidden in the laboratory, Dave witnesses Dr. Kozak infusing company head of state Lance Strictland with a medicine that will certainly immobilize him for numerous months, offering Kozak sufficient time to usurp control of the firm. After viewing safety electronic cameras, Kozak as well as his minions understand that somehow Dave ended up being a specific duplicate of Khyi Yang Po.
When Dave comes home, still in his canine kind, he overhears a chat in between Carly and also Josh that he and Rebecca might be splitting up. After hearing this, Dave then overturns a Scrabble online game as well as utilizes the letters to disclose as well as make clear all the previous events to them. However when Dave gets out of the house, he is caught by Kozak's minions.
Dave is required to the laboratory to be euthanized, but Kozak has a court summons, as well as should take care of Dave later. Right before he leaves, Kozak mocks Dave in canine form as well as is bitten in the process. He after that begins to exhibit the same issues Dave had at the start of his experience; Dave had successfully transferred the gene series right into Kozak.
In the courtroom, Dave calls Kozak back to the stand as well as attempts to obtain him to confess a few things he has done, yet Kozak manages to conceal his key. Thinking swiftly, he mocks Kozak by suggesting he was functioning under Strictland's shadow, and outrages him. The two begin grumbling at each one more, and also the court, exasperated by Dave's canine actions, orders the sheriff to eliminate him. But Dave handles to stimulate on Kozak's canine instincts, triggering a mutation in him, after which he is jailed. The pharmaceutical business is gone back to Strictland, the mutant animals are safeguarded, and Dave has the ability to spend more time with his family. The film finishes with the family vacationing in Hawaii, where Khyi Yang Po is seen browsing. Dave's canine practices somewhat continue to be, as he captures a Frisbee with his teeth in the closing scene.
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